Comprehensive, fully cited investigations into the biochemical mechanisms governing mitochondrial biogenesis, chronobiology, and metabolic longevity for adults over 50.
Cellular Bioenergetics
A comprehensive biochemical analysis examining electron transport chain efficiency, reactive oxygen species leakage, and the kinetics of PGC-1α coactivation in mature tissue.
Circadian Biology
Investigating the progressive loss of lens light transmission with age, its downstream impact on central melatonin suppression, and clinical protocols for phase advancement.
Musculoskeletal
Highlighting how contracting myofibers secrete protective cytokines (Irisin, IL-15) that cross the blood-brain barrier and regulate systemic glucose disposal.
Cellular Nutrition
Evaluating the kinetics of the salvage pathway enzymes NAMPT and NMNAT, oral bioavailability of precursor compounds, and synergy with CD38 inhibition.
Bioenergetics
Examining the eNOS uncoupling phenomenon and targeted dietary strategies to sustain microcapillary flow and cerebral perfusion in adults over 50.
Circadian Biology
Mapping the physiological timing required to trigger optimal macroautophagy and cerebral lymphatic drainage without inducing catabolic muscle wasting.